Oprah Talks Vacation Aboard Yacht with Obamas, Tom Hanks and Bruce Springsteen

It was a big night for Oprah Winfrey in NYC as she premiered her HBO project "The Immortal Life of Henrietta Lacks.”

Oprah was all smiles as she greeted “Extra's” AJ Calloway, who just welcomed his third child. “Hello you baby maker!” she said, joking, “I think it's time to stop, three is it, cause you can't manage… With three you're always going where is…”

When AJ told her the baby is his first boy. Oprah replied, “You have proven that your seed can produce a son. Done!”

She played coy when AJ asked about her recent vacation with President Obama, Michelle Obama, Tom Hanks and Bruce Springsteen on a $300-milllion, 450-foot yacht off the coast of Tahiti.

“I was on vacation, there were some people on vacation,” she said, adding, “The thing is I've been on that boat many times.”

When AJ mentioned Hanks, she said, “Tom Hanks is the funniest person I know,” adding, “This is the deal, what happens on the boat stays on the boat.” AJ asked if there were political conversations, “There were conversations all the time, that's all we did was talk, we talked and everybody else did a lot of paddle boarding. I'm not really good with the ocean. Me and the ocean don't get along too good, there was a lot of paddle boarding, snorkeling, jet skiing, lots of good stuff.”

AJ asked if with all the political talk anyone convinced her to run for office. Oprah asserted, “There was no talk of me running… I'm not running for office, there has never been any talk of me running for office.”

She also explained what happened earlier in the day when she was rushed away by security after a fight broke out as she was leaving CBS Studios. “We heard like a popping sound, when you hear pop… move!”

The 63-year-old, who is looking good and still following Weight Watchers, told AJ, “Counting those points baby, counting those points.”

Thrilled to be a part of getting the story of Henrietta Lacks made, she said, “It is an accomplishment to have gotten it done, I have sort of carried it with me since 2010.” She said she learned about Henrietta thanks to Rebecca Skloot's book by the same name.

The story is about a working-class African-American woman whose cervical cancer cells were used without her consent to create the first immortal human cell line. Oprah said she is sad Henrietta's daughter Deborah, who she plays in the movie, was not able to be there. “A lot of her children are here. Not everybody has a mother who made that kind of contribution in the world and has a film that will last forever that people will know forever who she was.”