The prosecution has accused Hernandez of murdering Odin Lloyd in June 2013, and Jenkins is considered the prosecution's key witness.
According to the Boston Herald, Jenkins, who was granted immunity in February, has been accused of tossing the murder weapon, hiding the Nike sneakers Hernandez was supposedly wearing at the crime scene, and lying to the grand jury.
She may have changed alliances since testifying before the grand jury, however, considering new evidence that Hernandez may have cheated multiple times.
Jenkins could drop a bombshell, or claim she doesn't remember the details.
Hernandez and co-defendants Ernest Wallace and Carlos Ortiz have been accused of killing Jenkins' sister's boyfriend Lloyd, who was found shot to death at an industrial park less than a mile from Hernandez and Jenkins' home.