Jennifer Aniston’s Wedding: What Chelsea Handler Knows

Bride-to-be Jennifer Aniston and late night host Chelsea Handler are best buds, but that doesn’t mean the comedienne will be standing by Jen’s side on her wedding day.

The “Chelsea Lately” host told “Extra’s” Terri Seymour that she won’t be maid of honor when Aniston ties the knot with fiancé Justin Theroux.

“Nooo, I'm not going to be maid of honor...because she has other friends that she is much closer too," she said. "We are good friends, but no she's not going to ask me. No, that would be really weird."

Jen will stop by “Chelsea Lately” on Monday for her first post-engagement interview. The gigantic engagement ring, however, won’t be up for discussion.

"We don't want to be gross," Chelsea joked with Eonline.com. "This isn't an ad for Zales -- which I'm sure is where Justin bought it."

Jen’s interview will kickoff the new season of “Chelsea Lately,” which features a new studio and lots of A-list guests, like Fergie and Miley Cyrus.

Friends Cameron Diaz and Gwyneth Paltrow even rapped about Chelsea’s new digs in a new music video. “Yo Chelsea, we hear that you got a brand new studio, but we know you got on TV by bein' a ho!” Watch!