The actress and her art advisor husband Will Kopelman welcomed the little girl on April 22. The couple also has a 20-month-old daughter named Olive.
Barrymore said she had to bounce back quickly after her second pregnancy. "I knew that I have two kids to take care of now and just kicked my own butt to get back into the swing of things immediately.”
She revealed that her biggest challenge is, "Just being split. They're awake and asleep at different times, or awake at the same time, and it's a juggling act a little bit."
Drew said she’s looking forward to raising a family very different from her own. She wanted Olive "to have a sibling, because I really would have liked that in my life… And always being on time, being there when I say I'm going to be there. Creating a real stable home. I know when my daughter wants to swing higher and jump into the pool and all of these things, she feels safe. To make your kids feel safe is everything."
So far, "Olive loves Frankie and just wants to hang out with her all the time. She wants to feed her. She's super into it. That's now. I'm sure things will ebb and flow."
Drew also admitted that she didn’t think she would go back to work after Olive was born, but that changed, in part because of her “Blended” co-star Adam Sandler.
"I didn't think I could go back to work, honestly. I didn't want to be away from my kids and it just wasn't the priority," she said. "With Adam, he makes everything really safe because he really creates an environment where kids can come and be a part of it. It was a really big lesson for me."
For Drew's album of intimate family photos with Frankie, Olive and Will, and more of her exclusive interview, pick up this week's issue of People, on newsstands Friday.