The three-time Oscar nominee died in New York of pneumonia brought on by acute myeloid leukemia, her son Jacob Bernstein told The New York Times.
Ephron started out as a newspaper reporter and wrote for "New Journalism" magazine. She became known for her satiric and witty essays in the 1960s and 1970s.
Ephron’s films often featured strong female roles, including dramas “Silkwood” and most recently “Julie & Julia.”
The daughter of writers Phoebe and Henry Ephron, and sister to three other writers, Nora has been married three times, to author Dan Greenberg, later to Watergate investigative reporter Carl Bernstein, and at the time of her death, to “Goodfellas” writer Nicholas Pileggi.
She is survived by Plieggi and two sons from her marriage to Bernstein
Nora Ephron, best known for penning such classic romantic comedies as “When Harry Met Sally” and “Sleepless in Seattle,” died on Tuesday. She was 71.