Actor David Arquette is the latest celeb to take a stand against bullying, as seen in a new PSA for MyLifeMyPower.org.

"Having a transgender sibling, Alexis, it's a subject that hits really close to home," Arquette told "Extra's" Terri Seymour. "I grew up with Alexis, who's very flamboyant, and the way kids treated her growing up was just unbelievable."

David's words for kids who are being bullied: "Just have confidence in yourself and embrace you uniqueness."

Check out behind-the-scenes footage of the making of Arquette's PSA.

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