His agent, Dave Bradley, confirmed that the actor died of liver and kidney failure.
The star had been in the hospital for the past four months. Bradley told EW that Lester had recently had his breathing tubes removed and has been moved from ICU to hospice care.
Lester addressed his health on Twitter last November, telling fans, "Liver & kidneys are starting to heal, Came close to dying! With out my fiancé (sic) Jennifer Worland, I wouldn't be alive.”
He battled his weight, at one point tipping the scales at more than 500 pounds. After undergoing gastric bypass surgery in 2000, he dropped to less than 200 pounds.