The couple adopted 4-year-old Millie, who was found homeless and searching for food scraps outside a restaurant in San Gabriel, Calif., earlier this month.
The San Gabriel Valley Human Society wrote on Facebook with an adorable pic, "ADOPTED! Millie was adopted by George Clooney and his wife Amal!! Millie, a bassett hound, now has a new brother named Louie who is also a rescue! Congratulations and thank you for adopting!!"
The adoption center added about the pair, "They did a 'meet and greet' with her and spent time introducing her to their other rescue, a cocker spaniel named Louie. It was good news that Millie and Louie hit it off and the happy, new family headed home together!"
George is also a parent to a cocker spaniel mix named Einstein, another rescue. His most famous pet so far was his 300-pound pig Max, which he owned for 18 years. Max died in 2006.