In the clip, Khloé was unhappy about Caitlyn's negative comments about mom Kris in Cait’s Vanity Fair cover story.
Khloé said, "I just said, 'We don't care what you're doing' -- meaning we don't care if you want to transition. We want to support you and be there for you. But, we don't think that that entails you speaking negatively about my mom. In our opinion, you don't even need to mention our mom... let's not drag my mom through the mud."
She added, "I would think you would come from a place of more compassion, especially when you have two young daughters who are greatly affected by it. And then when you try to tell me I don't know what I'm talking about."
In April, before Caitlyn's transition, she told Diane Sawyer that Khloé took her decision to transition very hard. She shared,"You would think out of all of the kids, Khloé is the most fun, open-minded… and that's not the case with Khloé. She's very emotional. She's had the toughest time with it, because she's had a lot of losses in her life. She lost her father at a young age. He died suddenly, cancer. You know, Lamar had his issues."
A new episode of "I Am Cait" airs Sunday night on E!