The Donald was confronted by FOX News moderator Megyn Kelly, who said to him, "You've called women you don't like 'fat pigs,' 'dogs,' 'slobs,' and 'disgusting animals'..."
Donald responded to her accusations by saying, "Only Rosie O'Donnell."
After Rosie caught wind of his response, she tweeted, "try explaining that 2 ur kids."
Trump and O'Donnell have had an ongoing feud for years, with Trump writing on Twitter last year, "Rosie is crude, rude, obnoxious and dumb - other than that I like her very much!"
After the debate, Donald lashed out at Megyn by tweeting, “Wow, @megynkelly really bombed tonight. People are going wild on twitter! Funny to watch."
In addition, he retweeted a man who wrote, "Fox viewers give low marks to bimbo @MegynKelly will consider other programs!"
Watch Trump highlights from last night’s debate!