Meyers paid homage to predecessor Jimmy Fallon with his own take on the “Thank You Notes” skit, signature piano music and all.
The premiere episode also meant a “Weekend Update” reunion for Seth and Amy Poehler. See the host interview his former “Saturday Night Live” co-star. When Poehler pretended to be a boring guest, Meyers quipped, "We have faked chemistry so well" in the past.
Vice President Joe Biden stopped by for the kickoff. Did he have a major announcement to make about his plans for 2016?
Watch the video to find out!