The 90-minute show will feature performances by Lady Gaga, Eminem, Avicii, Arcade Fire, Walk Off the Earth, and more.
The nominees include major music artists such as Rihanna, Taylor Swift, One Direction and Katy Perry, as well as rising stars Pentatonix, the Piano Guys and Lindsey Stirling.
Nominees were chosen based on views over the past 12 months. The awards include six categories: Video of the Year, Artist of the Year, Response of the Year, YouTube Phenomenon, YouTube Breakthrough and Innovation of the Year.
See the full list of nominees at Variety.com.
The inaugural YouTube Music Awards will be webcast live Sunday, November 3 at 3PM PT/6PM ET from New York's Pier 36 -- and you can watch the whole event below!