As the multi-hyphenated Madonna prepares to release her latest directorial effort, "W.E.," the superstar sat down with ABC news reporter Cynthia McFadden for a revealing interview, including her thoughts Lady Gaga.

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Tune in to "Nightline" on Thursday night, "Good Morning America" on Friday morning and "20/20" for more on Madonna. And don't forget to tweet #AskMadonna to be part of the conversation!

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