Lady Gaga Goes on a Gender Bender

Lady Gaga turned Lady Guy Guy in her 2011 MTV Music Video Award opening act!

Mother Monster emerged as her smoking, swearing alter male ego, "Jo Calderone", and gave an opening speech wearing Serge Gainsbourg-inspired, casual French suiting before launching into her latest single "You and I," with Queen's guitarist Brian May.

Watch!

Later, "Jo" introduced Britney Spears as this year's Michael Jackson Video Vanguard Award winner -- and the two almost kiss. Watch!

Get More: 2011 VMA, Music

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